Professor of Chemical Biology at Imperial College London and Head of Division of Computational and Systems Medicine. Her main research area focuses on applying metabolic profiling and computational modelling of biofluids and tissues to understand pathological and physiological processes. She has a broad background in metabolic chemistry, with specific expertise in spectroscopy and in chemometric modeling of spectral data. She began her research career investigating molecular mechanisms of toxicology using spectroscopic methods and then broadened the scope to research clinical pathologies in a range of clinical fields. Prof Holmes has several research projects investigating the consequences of modification of the gut microbiota and has particular interest in the gut-brain axis. This involves both the development and application of spectroscopic and chemometric methods, and in particular the fusion of metagenomic and metabonomic data to provide a readout of the functionality of the microbiome. She holds visiting Professorships with a number of universities including CEU Madrid and the Chinese Academy of Sciences in Wuhan. Prof Holmes has an H-index of 81 and is an ISI Highly Cited Researcher.