The National Phenome Centre

Metabolomic profiling in small vessel disease identifies multiple associations with disease severity

Harshfield EL, Sands CJ, Tuladhar AM, de Leeuw F-E, Lewis MR, Markus HS

medRxiv 2021.05.13.21257190

Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis

Andreas NJ, Basu Roy R, Gomez-Romero M, Horneffer-van der Sluis V, Lewis MR, Camuzeaux SSM, Jiménez B, Posma JM, Tientcheu L, Egere U, Sillah A, Togun T, Holmes E, Kampmann B.

Sci Rep. 2020 Apr 29;10(1):7302. doi: 10.1038/s41598-020-64413-6

Identifying the factors influencing outcome in probiotic studies in overweight and obese patients: host or microbiome?

Mullish BH, Michael DR, McDonald JAK, Masetti G, Plummer SF, Marchesi JR

Gut Published Online First: 21 April 2020. doi: 10.1136/gutjnl-2020-321110

Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths

Giallourou N, Fardus-Reid F, Panic G, Veselkov K, McCormick BJJ, Olortegui MP, Ahmed T, Mduma E, Yori PP, Mahfuz M, Svensen E, Ahmed MMM, Colston JM, Kosek MN, Swann JR

Sci Adv. 2020 Apr 8;6(15):eaay5969. doi: 10.1126/sciadv.aay5969

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Wang X, Nijman R, Camuzeaux S, Sands C, Jackson H, Kaforou M, Emonts M, Herberg JA, Maconochie I, Carrol ED, Paulus SC, Zenz W, Van der Flier M, de Groot R, Martinon-Torres F, Schlapbach LJ, Pollard AJ, Fink C, Kuijpers TT, Anderson S, Lewis MR, Levin M, McClure M; EUCLIDS consortium.

Sci Rep. 2019 Nov 27;9(1):17714. doi: 10.1038/s41598-019-53721-1

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis.

Ovadia C, Perdones-Montero A, Spagou K, Smith A, Sarafian MH, Gomez-Romero M, Bellafante E, Clarke LCD, Sadiq F, Nikolova V, Mitchell A, Dixon PH, Santa-Pinter N, Wahlström A, Abu-Hayyeh S, Walters JRF, Marschall HU, Holmes E, Marchesi JR, Williamson C.

Hepatology. 2019 Jul;70(1):276-293. doi: 10.1002/hep.30661

Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease.

Tzoulaki I, Castagné R, Boulangé CL, Karaman I, Chekmeneva E, Evangelou E, Ebbels TMD, Kaluarachchi MR, Chadeau-Hyam M, Mosen D, Dehghan A, Moayyeri A, Ferreira DLS, Guo X, Rotter JI, Taylor KD, Kavousi M, de Vries PS, Lehne B, Loh M, Hofman A, Nicholson JK, Chambers J, Gieger C, Holmes E, Tracy R, Kooner J, Greenland P, Franco OH, Herrington D, Lindon JC, Elliott P.

Eur Heart J. 2019 May 18. pii: ehz235. doi: 10.1093/eurheartj/ehz235. [Epub ahead of print]

Colocalization Features for Classification of Tumors Using Desorption Electrospray Ionization Mass Spectrometry Imaging.

Inglese P, Correia G, Pruski P, Glen RC, Takats Z.

Anal Chem. 2019 May 21;91(10):6530-6540. doi: 10.1021/acs.analchem.8b05598

Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts.

Whiley L, Nye LC, Grant I, Andreas N, Chappell KE, Sarafian MH, Misra R, Plumb RS, Lewis MR, Nicholson JK, Holmes E, Swann JR, Wilson ID.

Anal Chem. 2019 Apr 16;91(8):5207-5216. doi: 10.1021/acs.analchem.8b05884

Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension.

Harbaum L, Ghataorhe P, Wharton J, Jiménez B, Howard LSG, Gibbs JSR, Nicholson JK, Rhodes CJ, Wilkins MR.

Thorax. 2019 Apr;74(4):380-389. doi: 10.1136/thoraxjnl-2018-212144

Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate.

Gafson AR, Savva C, Thorne T, David M, Gomez-Romero M, Lewis MR, Nicholas R, Heslegrave A, Zetterberg H, Matthews PM.

Neurol Neuroimmunol Neuroinflamm. 2019 Apr 22;6(3):e562. doi: 10.1212/NXI.0000000000000562

Lipoprotein markers associated with disability from multiple sclerosis.

Gafson AR, Thorne T, McKechnie CIJ, Jimenez B, Nicholas R, Matthews PM.

Sci Rep. 2018 Nov 19;8(1):17026. doi: 10.1038/s41598-018-35232-7

Metabolic phenotype of skeletal muscle in early critical illness.

Puthucheary ZA, Astin R, Mcphail MJW, Saeed S, Pasha Y, Bear DE, Constantin D, Velloso C, Manning S, Calvert L, Singer M, Batterham RL, Gomez-Romero M, Holmes E, Steiner MC, Atherton PJ, Greenhaff P, Edwards LM, Smith K, Harridge SD, Hart N, Montgomery HE.

Thorax. 2018 Oct;73(10):926-935. doi: 10.1136/thoraxjnl-2017-211073

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

Izzi-Engbeaya C, Comninos AN, Clarke SA, Jomard A, Yang L, Jones S, Abbara A, Narayanaswamy S, Eng PC, Papadopoulou D, Prague JK, Bech P, Godsland IF, Bassett P, Sands C, Camuzeaux S, Gomez-Romero M, Pearce JTM, Lewis MR, Holmes E, Nicholson JK, Tan T, Ratnasabapathy R, Hu M, Carrat G, Piemonti L, Bugliani M, Marchetti P, Johnson PR, Hughes SJ, James Shapiro AM, Rutter GA, Dhillo WS.

Diabetes Obes Metab. 2018 Dec;20(12):2800-2810. doi: 10.1111/dom.13460

Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms.

Bray R, Cacciatore S, Jiménez B, Cartwright R, Digesu A, Fernando R, Holmes E, Nicholson JK, Bennett PR, MacIntyre DA, Khullar V.

J Proteome Res. 2017 Nov 3;16(11):4208-4216. doi: 10.1021/acs.jproteome.7b00568

How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers.

Ferrario C, Statello R, Carnevali L, Mancabelli L, Milani C, Mangifesta M, Duranti S, Lugli GA, Jimenez B, Lodge S, Viappiani A, Alessandri G, Dall'Asta M, Del Rio D, Sgoifo A, van Sinderen D, Ventura M, Turroni F.

Front Microbiol. 2017 Sep 12;8:1749. doi: 10.3389/fmicb.2017.01749

Metabolic Profiling in Patients with Pneumonia on Intensive Care.

Antcliffe D, Jiménez B, Veselkov K, Holmes E, Gordon AC.

EBioMedicine. 2017 Apr;18:244-253. doi: 10.1016/j.ebiom.2017.03.034

Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study.

Maitre L, Villanueva CM, Lewis MR, Ibarluzea J, Santa-Marina L, Vrijheid M, Sunyer J, Coen M, Toledano MB.

BMC Med. 2016 Nov 4;14(1):177. doi: 10.1186/s12916-016-0706-3

Hepatocellular carcinoma: Review of disease and tumor biomarkers.

Kim JU, Shariff MI, Crossey MM, Gomez-Romero M, Holmes E, Cox IJ, Fye HK, Njie R, Taylor-Robinson SD.

World J Hepatol. 2016 Apr 8;8(10):471-84. doi: 10.4254/wjh.v8.i10.471

Plasma Lipid Profiling in a Rat Model of Hepatocellular Carcinoma: Potential Modulation Through Quinolone Administration.

Shariff MI, Tognarelli JM, Lewis MR, Want EJ, Mohamed Fel Z, Ladep NG, Crossey MM, Khan SA, Jalan R, Holmes E, Taylor-Robinson SD.

J Clin Exp Hepatol. 2015 Dec;5(4):286-94. doi: 10.1016/j.jceh.2015.07.205

Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis.

McPhail MJW, Shawcross DL, Lewis MR, Coltart I, Want EJ, Antoniades CG, Veselkov K, Triantafyllou E, Patel V, Pop O, Gomez-Romero M, Kyriakides M, Zia R, Abeles RD, Crossey MME, Jassem W, O'Grady J, Heaton N, Auzinger G, Bernal W, Quaglia A, Coen M, Nicholson JK, Wendon JA, Holmes E, Taylor-Robinson SD.

J Hepatol. 2016 May;64(5):1058-1067. doi: 10.1016/j.jhep.2016.01.003

A Comparison of DESI-MS and LC-MS for the Lipidomic Profiling of Human Cancer Tissue.

Abbassi-Ghadi N, Jones EA, Gomez-Romero M, Golf O, Kumar S, Huang J, Kudo H, Goldin RD, Hanna GB, Takats Z.

J Am Soc Mass Spectrom. 2016 Feb;27(2):255-64. doi: 10.1007/s13361-015-1278-8

Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis.

Lamour SD, Gomez-Romero M, Vorkas PA, Alibu VP, Saric J, Holmes E, Sternberg JM.

PLoS Negl Trop Dis. 2015 Oct 27;9(10):e0004200. doi: 10.1371/journal.pntd.0004200

Multiplatform characterization of dynamic changes in breast milk during lactation.

Andreas NJ, Hyde MJ, Gomez-Romero M, Lopez-Gonzalvez MA, Villaseñor A, Wijeyesekera A, Barbas C, Modi N, Holmes E, Garcia-Perez I.

Electrophoresis. 2015 Sep;36(18):2269-2285. doi: 10.1002/elps.201500011

Metabolic Profiling of Children Undergoing Surgery for Congenital Heart Disease.

Correia GD, Wooi Ng K, Wijeyesekera A, Gala-Peralta S, Williams R, MacCarthy-Morrogh S, Jiménez B, Inwald D, Macrae D, Frost G, Holmes E, Pathan N.

Crit Care Med. 2015 Jul;43(7):1467-76. doi: 10.1097/CCM.0000000000000982

Novel cystine ester mimics for the treatment of cystinuria-induced urolithiasis in a knockout mouse model.

Sahota A, Parihar JS, Capaccione KM, Yang M, Noll K, Gordon D, Reimer D, Yang I, Buckley BT, Polunas M, Reuhl KR, Lewis MR, Ward MD, Goldfarb DS, Tischfield JA.

Urology. 2014 Nov;84(5):1249.e9-15. doi: 10.1016/j.urology.2014.07.043

Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans.

Ladep NG, Dona AC, Lewis MR, Crossey MM, Lemoine M, Okeke E, Shimakawa Y, Duguru M, Njai HF, Fye HK, Taal M, Chetwood J, Kasstan B, Khan SA, Garside DA, Wijeyesekera A, Thillainayagam AV, Banwat E, Thursz MR, Nicholson JK, Njie R, Holmes E, Taylor-Robinson SD.

Hepatology. 2014 Oct;60(4):1291-301. doi: 10.1002/hep.27264

Rapid diagnosis and staging of colorectal cancer via high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy of intact tissue biopsies.

Mirnezami R, Jiménez B, Li JV, Kinross JM, Veselkov K, Goldin RD, Holmes E, Nicholson JK, Darzi A.

Ann Surg. 2014 Jun;259(6):1138-49. doi: 10.1097/SLA.0b013e31829d5c45

Chemical mapping of the colorectal cancer microenvironment via MALDI imaging mass spectrometry (MALDI-MSI) reveals novel cancer-associated field effects.

Mirnezami R, Spagou K, Vorkas PA, Lewis MR, Kinross J, Want E, Shion H, Goldin RD, Darzi A, Takats Z, Holmes E, Cloarec O, Nicholson JK.

Mol Oncol. 2014 Feb;8(1):39-49. doi: 10.1016/j.molonc.2013.08.010

Metabonomic profiling: a novel approach in neuroendocrine neoplasias.

Kinross JM, Drymousis P, Jiménez B, Frilling A.

Surgery. 2013 Dec;154(6):1185-92; discussion 1192-3. doi: 10.1016/j.surg.2013.06.018

Intraoperative tissue identification using rapid evaporative ionization mass spectrometry.

Balog J, Sasi-Szabó L, Kinross J, Lewis MR, Muirhead LJ, Veselkov K, Mirnezami R, Dezső B, Damjanovich L, Darzi A, Nicholson JK, Takáts Z.

Sci Transl Med. 2013 Jul 17;5(194):194ra93. doi: 10.1126/scitranslmed.3005623

A genome-wide assessment of variability in human serum metabolism.

Hong MG, Karlsson R, Magnusson PK, Lewis MR, Isaacs W, Zheng LS, Xu J, Grönberg H, Ingelsson E, Pawitan Y, Broeckling C, Prenni JE, Wiklund F, Prince JA.

Hum Mutat. 2013 Mar;34(3):515-24. doi: 10.1002/humu.22267

1H HR-MAS NMR spectroscopy of tumor-induced local metabolic “field-effects” enables colorectal cancer staging and prognostication.

Jiménez B, Mirnezami R, Kinross J, Cloarec O, Keun HC, Holmes E, Goldin RD, Ziprin P, Darzi A, Nicholson JK.

J Proteome Res. 2013 Feb 1;12(2):959-68. doi: 10.1021/pr3010106

Metabolic Phenotypes of Carotid Atherosclerotic Plaques Relate to Stroke Risk: An Exploratory Study.

Vorkas PA, Shalhoub J, Lewis MR, Spagou K, Want EJ, Nicholson JK, Davies AH, Holmes E.

Eur J Vasc Endovasc Surg. 2016 Jul;52(1):5-10. doi: 10.1016/j.ejvs.2016.01.022

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